Vitamin A and vitamin A derivatives, also termed herein retinoids”, corresponding to retinoic acid, isoretinoic acid, retinol and retinal are another class of keratolytically energetic brokers.
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The invention pertains to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a floor-energetic agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. How the nationality of an ‘unprefixd’ ship could be designated is one other matter, I do not see the need for ‘His Majesty’s Ship’ etc, notably as there wasn’t a laid down type of nomenclature on the time (an article on RN Ship naming can be forthcoming).
One other group of keratolytically active agents include alpha-hydroxy acids, equivalent to lactic acid and glycolic acid and their respective salts and derivatives; and beta-hydroxy acids, reminiscent of salicylic acid (-hydroxybenzoic acid) and salicylic acid salts and pharmaceutically acceptable derivatives.
2. The foamable composition of claim 1, wherein the provider additional includes a therapeutically effective quantity of at the very least one active agent. 8. The foamable composition of claim 1, wherein the floor-energetic agent is present at about zero.three% to about 6.25% by weight of the provider.
Appropriate pores and skin lightening or whitening brokers embody those identified within the artwork, together with hydroquinone, azelaic acid and different associated dicarboxylic acids, and salts and derivatives thereof, retinoids, kojic acid, arbutin, nicotinic acid and nicotinic acid precursors, salts and derivatives, ascorbic acid and salts and derivatives thereof (e.g., magnesium ascorbyl phosphate or sodium ascorbyl phosphate), and herbal extracts (e.g., mulberry extract, placental extract).
Gelling agents include, but should not restricted to, naturally-occurring polymeric supplies resembling, locust bean gum, sodium alginate, sodium caseinate, egg albumin, gelatin agar, carrageenin gum sodium alginate, xanthan gum, quince seed extract, tragacanth gum, starch, chemically modified starches and the like, semi-synthetic polymeric supplies reminiscent of cellulose ethers (e.g. hydroxyethyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxy propylmethyl cellulose), micro-crystalline cellulose and compositions (Avicel sorts) manufactured by FMC, polyvinylpyrrolidone, polyvinylalcohol, guar gum, hydroxypropyl guar gum, soluble starch, cationic celluloses, cationic guars and the like and synthetic polymeric supplies reminiscent of carboxyvinyl polymers, polyvinylpyrrolidone, polyvinyl alcohol polyacrylic acid polymers, polymethacrylic acid polymers, polyvinyl acetate polymers, polyvinyl chloride polymers, polyvinylidene chloride polymers and the like.
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The pharmaceutical or cosmetic foam carrier optionally consists of a variety of pharmaceutical or beauty components, that are added in order to fantastic-tune the consistency of the formulation, protect the formulation parts from degradation and oxidation and bestow their beauty acceptability. The froth carrier or foam composition is actually freed from brief chain aliphatic alcohols (i.e., methyl, ethyl, isopropyl and butyl alcohol), not like the composition disclosed in U.S. Pat.
The term keratolytically lively agent” as used herein includes a compound that loosens and removes the stratum corneum of the pores and skin, or alters the construction of the keratin layers of skin. I labored for a number of hours on a new article, and I know I hit “save changes” dozens of occasions.